Cbio A/S is a biopharmaceutical company dedicated to curing cancer patients by making T-cell based immunotherapies available for patients worldwide. We focus on the so-called Tumor Infiltrating Lymphocyte – or TIL therapy, which is the most promising cell-based treatment for solid tumors.
Cbio’s mission is to develop and bring next-generation cell-based immunotherapies to cancer patients worldwide.
Pursuing our mission, we are developing next generation TIL therapies for solid tumors, accounting for 90% of all cancers. Our transformative new TIL product – novoleucel – enables more patients to be treated due to its minimal invasiveness, a broader T-cell repertoire, its short production time and industrial scalability without compromising yield.
Søborg
Cbio is located in Søborg, Copenhagen, in a 1,000 m2 state-of-the-art facility holding a manufacturing authorization to produce cell-based Advanced Therapy Medicinal Products (ATMPs) for clinical use. The facility is hosting the Company’s research, development and manufacturing activities and has cleanroom facilities with a current capacity to produce TIL products for up to 150 patients per year. Cbio is planning to further expand the cleanroom infrastructure in order to increase the capacity to up to 600 TIL patients per year.
Cbio and Karolinska Intitute in Stockholm is working together to advance TIL therapy to clinical phase I/II testing in cervical cancer patients. Karolinska has through the years been one of the key pioneers in advancing TIL therapy and immune-oncology in general.
Cbio has established a 3-year research collaboration with Krister Wennerberg’s group at the Biotech Research and Innovation Centre, University of Copenhagen (BRIC). The aim of the project is to improve the TIL therapy product, make the production process more scalable and potentially further improve Cbio’s proprietary TIL stimulator cocktail using high-throughput screening facilities at BRIC. The project is supported by the Innovation Fund Denmark through the industry PhD program.
Cbio is collaborating with Odense University Hospital with the aim to develop and pre-clinically optimize TIL products for colorectal, kidney, ovarian and pancreatic cancer patients. The collaboration entails 4 clinical departments as well as the Pathological Institute and is approved by the Ethical Committee from Region South Denmark. By combining Cbio’s unique knowhow on TIL stimulators and ways to also generate successful TIL products from less immunogenic tumors with Odense’s pathologist expertise, the aim is to develop TIL products for these four cancer indications that could be tested clinically at a later stage.